Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.64 |
| ▸ | BACE2 | Q9Y5Z0 | 10/20 | 0.64 |
| ▸ | CTSD | P07339 | 5/20 | 0.64 |
| ▸ | APP | P05067 | 2/20 | 0.62 |
| ▸ | REN | P00797 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240122 | 0.91 | BACE1 (0.76) | BACE1BACE2CTSDAPPREN | |
| Trifluoroacetic Acid SCHEMBL4236589 | 0.91 | BACE1 (0.69) | BACE1BACE2CTSD | |
| Trifluoroacetic Acid SCHEMBL4232950 | 0.89 | BACE1 (0.78) | BACE1BACE2CTSDAPPREN | |
| Trifluoroacetic Acid SCHEMBL4233764 | 0.85 | BACE1 (0.65) | BACE1BACE2CTSDAPPREN | |
| Trifluoroacetic Acid SCHEMBL4232734 | 0.85 | BACE1 (0.82) | BACE1BACE2CTSDAPPREN | |
| Trifluoroacetic Acid SCHEMBL4241065 | 0.84 | BACE1 (0.64) | BACE1BACE2CTSDAPPREN | |
| Trifluoroacetic Acid SCHEMBL4237797 | 0.83 | BACE1 (0.63) | BACE1BACE2CTSD | |
| Trifluoroacetic Acid SCHEMBL4235536 | 0.82 | BACE1 (0.71) | BACE1BACE2CTSD | |
| Trifluoroacetic Acid SCHEMBL4234502 | 0.82 | BACE1 (0.71) | BACE1BACE2CTSD | |
| Trifluoroacetic Acid SCHEMBL4238985 | 0.81 | BACE1 (0.84) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176850-A1 | Novel 2-Amino-Imidazole-4-One Compounds And Their Use In The Manufacture Of A Medicament To Be Used In The Treatment Of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration And Dementia | ASTRAZENECA AB (SE) | 2009-07-09 | — | — | US | claimed |
| CN-101360716-A | Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer s disease, neurodegeneration and dementia | ASTRAZENECA AB (SE) | 2009-02-04 | — | — | CN | claimed |
| US-20090176850-A1 | Novel 2-Amino-Imidazole-4-One Compounds And Their Use In The Manufacture Of A Medicament To Be Used In The Treatment Of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration And Dementia | ASTRAZENECA AB (SE) | 2009-07-09 | — | — | US | disclosed |
| CN-101360716-A | Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer s disease, neurodegeneration and dementia | ASTRAZENECA AB (SE) | 2009-02-04 | — | — | CN | disclosed |
| EP-1954682-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058601-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176850-A1 | Novel 2-Amino-Imidazole-4-One Compounds And Their Use In The Manufacture Of A Medicament To Be Used In The Treatment Of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration And Dementia | PSEN2, MAPT, PSEN1 | BACE1 7/4885BACE2 26/4885CTSD 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.