Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 14/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | FABP6 | P51161 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234522 | 0.90 | CCR8 (0.54) | CCR8KCNH2CYP3A4CYP2D6 | |
| SCHEMBL4235418 | 0.87 | CCR8 (0.48) | CCR8KCNH2NAMPTCYP3A4CYP2D6 | |
| SCHEMBL4233184 | 0.86 | CCR8 (0.53) | CCR8KCNH2NAMPTCYP3A4CYP2D6 | |
| SCHEMBL4234983 | 0.86 | CCR8 (0.51) | CCR8KCNH2CYP3A4CYP2D6 | |
| SCHEMBL4234930 | 0.85 | CCR8 (0.51) | CCR8KCNH2NAMPTCYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4234461 | 0.85 | CCR8 (0.61) | CCR8KCNH2CYP3A4CYP2D6 | |
| SCHEMBL4234515 | 0.84 | CCR8 (0.49) | CCR8KCNH2CYP3A4CYP2D6 | |
| SCHEMBL4234941 | 0.84 | CCR8 (0.66) | CCR8KCNH2CYP3A4CYP2D6FABP6 | |
| SCHEMBL4230558 | 0.83 | CCR8 (0.48) | CCR8KCNH2CYP3A4CYP2D6 | |
| SCHEMBL4237649 | 0.83 | CCR8 (0.45) | CCR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | CCR8, CCR1, CCR10 | CCR8 1/4885KCNH2 3143/4885NAMPT 4494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.