Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 15/20 | 0.33 |
| ▸ | CDK2 | P24941 | 15/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.33 |
| ▸ | AURKA | O14965 | 7/20 | 0.33 |
| ▸ | PLK1 | P53350 | 6/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.32 |
| ▸ | CCND3 | P30281 | 2/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.32 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.32 |
| ▸ | FOS | P01100 | 1/20 | 0.31 |
| ▸ | JUN | P05412 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424681 | 0.91 | MAPKAPK2 (0.46) | MAPKAPK2CCNA2CDK2CCNA1AURKA | |
| SCHEMBL428160 | 0.90 | CCNA2 (0.38) | MAPKAPK2CCNA2CDK2CCNA1AURKA | |
| SCHEMBL429043 | 0.89 | MAPKAPK2 (0.35) | MAPKAPK2CCNA2CDK2CCNA1AURKA | |
| SCHEMBL430545 | 0.89 | CCNA2 (0.41) | MAPKAPK2CCNA2CDK2CCNA1AURKA | |
| SCHEMBL424939 | 0.85 | IRAK1 (0.34) | MAPKAPK2CFTRCCNA2CDK2CCNA1 | |
| SCHEMBL428910 | 0.84 | MAPKAPK2 (0.45) | MAPKAPK2CCNA2CDK2CCNA1AURKA | |
| SCHEMBL429822 | 0.83 | MAPKAPK2 (0.38) | MAPKAPK2CCNA2CDK2CCNA1AURKA | |
| SCHEMBL428168 | 0.83 | MAPKAPK2 (0.40) | MAPKAPK2CCNA2CDK2CCNA1AURKA | |
| SCHEMBL431590 | 0.82 | MAPKAPK2 (0.40) | MAPKAPK2CFTR | |
| SCHEMBL431842 | 0.82 | MAPKAPK2 (0.48) | MAPKAPK2CCNA2CDK2CCNA1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022030-A1 | Tetracyclic Lactame Derivatives | NOVARTIS AG | 2012-01-26 | — | — | US | disclosed |
| US-7838674-B2 | 2-(1-amino-cyclobutylmethyl)-8-(4-methoxy-phenyl)-4,5-dihydro-1 H-1,7,9-triazacyclopenta[a]naph-thalene-3-carboxylic acid lactame; useful especially as inhibitors of mitogen-activated protein kinase-activated protein kinase-2 (MK2 or MAPKAP kinase-2 | NOVARTIS AG (CH) | 2010-11-23 | — | — | US | disclosed |
| US-20090098218-A1 | Tetracyclic Lactame Derivatives | NOVARTIS AG | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022030-A1 | Tetracyclic Lactame Derivatives | TNF, RPS6KB2, RPS6KA2 | MAPKAPK2 480/4885CFTR 1160/4885CCNA2 23/4885 |
| US-20090098218-A1 | Tetracyclic Lactame Derivatives | TNF, RPS6KB2, RPS6KA2 | MAPKAPK2 480/4885CFTR 1160/4885CCNA2 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.