Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 17/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4230577 | 0.88 | SSTR5 (0.44) | SSTR5HRH1KCNH2SYKSSTR3 | |
| SCHEMBL4232885 | 0.86 | SSTR5 (0.46) | SSTR5HRH1SSTR1KCNH2SSTR3 | |
| SCHEMBL4236956 | 0.80 | SSTR5 (0.43) | SSTR5HRH1SSTR1KCNH2SYK | |
| SCHEMBL3775485 | 0.79 | SSTR5 (0.57) | SSTR5HRH1SSTR1KCNH2SYK | |
| SCHEMBL4230352 | 0.79 | SSTR5 (0.43) | SSTR5HRH1SSTR1KCNH2SSTR3 | |
| SCHEMBL4232220 | 0.78 | SSTR5 (0.46) | SSTR5HRH1KCNH2SSTR3 | |
| SCHEMBL4236962 | 0.77 | HTR2C (0.42) | SSTR5HRH1SSTR1KCNH2SYK | |
| SCHEMBL4232088 | 0.77 | SSTR5 (0.44) | SSTR5HRH1SSTR1KCNH2SSTR3 | |
| SCHEMBL4236623 | 0.77 | SSTR5 (0.41) | SSTR5KCNH2SSTR3 | |
| SCHEMBL4953703 | 0.76 | SSTR5 (0.50) | SSTR5HRH1SSTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |