Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 17/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.73 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4242368 | 0.95 | CCR8 (0.67) | CCR8KCNH2DPP4DPP9CYP2D6 | |
| SCHEMBL4237544 | 0.85 | CCR8 (0.77) | CCR8KCNH2CYP2D6 | |
| SCHEMBL4233158 | 0.85 | CCR8 (0.71) | CCR8KCNH2CYP2D6 | |
| SCHEMBL4242372 | 0.85 | CCR8 (0.54) | CCR8KCNH2DPP4DPP9 | |
| SCHEMBL4243098 | 0.84 | CCR8 (1.00) | CCR8KCNH2CYP2D6 | |
| SCHEMBL4230112 | 0.84 | CCR8 (0.82) | CCR8KCNH2CYP2D6CHRM2 | |
| SCHEMBL4235585 | 0.83 | CCR8 (0.74) | CCR8KCNH2CYP2D6 | |
| SCHEMBL4234643 | 0.83 | CCR8 (0.79) | CCR8KCNH2CYP2D6CHRM2 | |
| SCHEMBL5033902 | 0.83 | CCR8 (0.70) | CCR8KCNH2CYP2D6CHRM2 | |
| SCHEMBL4237911 | 0.83 | CCR8 (0.70) | CCR8KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | US | claimed |
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156575-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | CCR8, CCR1, CCR10 | CCR8 1/4885KCNH2 3143/4885DPP4 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.