Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 16/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233681 | 0.92 | SSTR5 (0.41) | SSTR5KCNH2SSTR3DRD2DRD4 | |
| SCHEMBL4230352 | 0.92 | SSTR5 (0.43) | SSTR5KCNH2SSTR3DRD2DRD4 | |
| SCHEMBL4232809 | 0.90 | SSTR5 (0.41) | SSTR5KCNH2SSTR3DRD2DRD4 | |
| SCHEMBL4233363 | 0.89 | SSTR5 (0.44) | SSTR5KCNH2DRD2DRD4DRD3 | |
| SCHEMBL4225162 | 0.89 | CYP19A1 (0.39) | SSTR5DRD2DRD4DRD3SLC6A2 | |
| SCHEMBL4234809 | 0.89 | SSTR5 (0.44) | SSTR5KCNH2DRD2DRD4DRD3 | |
| SCHEMBL4231311 | 0.89 | SSTR5 (0.48) | SSTR5KCNH2 | |
| SCHEMBL4232220 | 0.88 | SSTR5 (0.46) | SSTR5KCNH2SSTR3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL4235376 | 0.85 | SSTR5 (0.42) | SSTR5KCNH2SSTR3 | |
| SCHEMBL4235018 | 0.82 | SSTR5 (0.41) | SSTR5DRD2DRD4DRD3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |