SCHEMBL4238071

SCHEMBL4238071

COCCOCc1ccc2ccc(CN3CCC(NC(=O)c4ccc(CO)cc4)CC3)cc2c1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 2/20 0.59
MCHR1 Q99705 14/20 0.59
DRD4 P21917 4/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4240454 0.93 CCR3 (0.59) CCR3MCHR1DRD4
SCHEMBL3149781 0.92 CCR3 (0.72) CCR3MCHR1DRD4
SCHEMBL4246600 0.91 MCHR1 (0.72) CCR3MCHR1DRD4
SCHEMBL3145256 0.91 MCHR1 (0.63) CCR3MCHR1DRD4
SCHEMBL4236492 0.90 DRD4 (0.71) MCHR1DRD4
SCHEMBL4246591 0.89 MCHR1 (0.66) CCR3MCHR1DRD4
SCHEMBL3145239 0.88 MCHR1 (0.64) CCR3MCHR1DRD4
SCHEMBL4238501 0.87 MCHR1 (0.56) CCR3MCHR1DRD4
SCHEMBL4238205 0.87 MCHR1 (0.65) CCR3MCHR1DRD4
SCHEMBL4234340 0.87 MCHR1 (0.75) CCR3MCHR1DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2098509-A1 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE Taisho Pharmaceutical Co. Ltd. (JP) 2009-09-09 EP disclosed