Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 3/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324570 | 0.87 | CHRNB4 (0.51) | CHRNB4CHRNA3ACP1IKBKBCHUK | |
| SCHEMBL3321341 | 0.87 | CHRNB4 (0.51) | CHRNB4CHRNA3ACP1IKBKBCHUK | |
| SCHEMBL13333549 | 0.83 | CHRNB4 (0.65) | CHRNB4CHRNA3ACP1IKBKBCHUK | |
| SCHEMBL3325177 | 0.83 | IKBKB (0.47) | CHRNB4CHRNA3ACP1IKBKBCHUK | |
| SCHEMBL3325101 | 0.83 | IKBKB (0.47) | CHRNB4CHRNA3ACP1IKBKBCHUK | |
| SCHEMBL3321366 | 0.82 | IKBKB (0.48) | CHRNB4CHRNA3ACP1IKBKBCHUK | |
| SCHEMBL3321227 | 0.82 | IKBKB (0.48) | CHRNB4CHRNA3ACP1IKBKBCHUK | |
| SCHEMBL3329967 | 0.82 | CHRNB4 (0.48) | CHRNB4CHRNA3IKBKBCHUKCHRNB2 | |
| SCHEMBL3325361 | 0.82 | CHRNB4 (0.48) | CHRNB4CHRNA3IKBKBCHUKCHRNB2 | |
| SCHEMBL3117931 | 0.81 | IKBKB (0.47) | CHRNB4CHRNA3IKBKBCHUKCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066630-A1 | PIPERIDINE DERIVATIVES | Pfizer Products Incorporated (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008023258-A1 | PIPERIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-28 | — | — | WO | disclosed |