Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.54 |
| ▸ | PLK1 | P53350 | 9/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | FES | P07332 | 2/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.51 |
| ▸ | TAF1 | P21675 | 2/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | NEK2 | P51955 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053040 | 1.00 | BRD4 (0.54) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4242806 | 0.92 | BRD4 (0.54) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4242812 | 0.92 | BRD4 (0.54) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4240072 | 0.91 | PTK2 (0.55) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4240068 | 0.91 | PTK2 (0.55) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4238700 | 0.91 | AURKA (0.57) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4238706 | 0.91 | AURKA (0.57) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4234729 | 0.91 | BRD4 (0.55) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4234733 | 0.91 | BRD4 (0.55) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4247616 | 0.89 | PTK2 (0.57) | BRD4PLK1BRDTAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |