Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 10/20 | 0.53 |
| ▸ | AKT1 | P31749 | 8/20 | 0.53 |
| ▸ | AKT2 | P31751 | 7/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.53 |
| ▸ | RPS6KA1 | Q15418 | 4/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061120 | 0.89 | AKT1 (0.63) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| SCHEMBL5058413 | 0.87 | ROCK1 (0.50) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| Trifluoroacetic Acid SCHEMBL5058483 | 0.86 | AKT1 (0.58) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| Trifluoroacetic Acid SCHEMBL5067623 | 0.83 | ROCK1 (0.47) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| SCHEMBL4065038 | 0.82 | AKT1 (0.60) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| SCHEMBL4062274 | 0.82 | RPS6KA5 (0.52) | RPS6KA5AKT1ROCK1RPS6KA1RPS6KB1 | |
| SCHEMBL4065044 | 0.81 | AKT1 (0.58) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| SCHEMBL4070051 | 0.81 | AKT1 (0.58) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| SCHEMBL4064891 | 0.81 | AKT1 (0.61) | RPS6KA5AKT1AKT2ROCK1AKT3 | |
| SCHEMBL4236722 | 0.80 | AKT1 (0.54) | RPS6KA5AKT1AKT2ROCK1AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | claimed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | claimed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | claimed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | RPS6KA5 156/4885AKT1 5/4885AKT2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.