Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 7/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.53 |
| ▸ | PLK1 | P53350 | 4/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235611 | 0.89 | IGF1R (0.64) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4236731 | 0.87 | IGF1R (0.61) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4238681 | 0.86 | AURKA (0.56) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4241071 | 0.85 | IGF1R (0.58) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4238497 | 0.85 | BRD4 (0.55) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4238720 | 0.85 | IGF1R (0.60) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4226614 | 0.85 | IGF1R (0.60) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4240691 | 0.85 | BRD4 (0.64) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4240316 | 0.85 | BRD4 (0.55) | BRD4AURKAAURKBIGF1RLRRK2 | |
| SCHEMBL4238700 | 0.84 | AURKA (0.57) | BRD4AURKAAURKBIGF1RLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112524-A1 | PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |