Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 7/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2754353 | 0.90 | PDPK1 (0.41) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL2753753 | 0.87 | PDPK1 (0.43) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL4402761 | 0.87 | PDPK1 (0.43) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL2752042 | 0.86 | PDPK1 (0.43) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL2752053 | 0.86 | PDPK1 (0.43) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL2752909 | 0.86 | PDPK1 (0.39) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL2752466 | 0.85 | PDPK1 (0.42) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL2753841 | 0.84 | PDPK1 (0.42) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL2752105 | 0.84 | PDPK1 (0.43) | PDPK1WNT1GSK3BDYRK1ABRD4 | |
| SCHEMBL4403723 | 0.84 | PDPK1 (0.43) | PDPK1WNT1GSK3BDYRK1ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109611-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | Eisai R&D Management Co., Ltd. (JP) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008095944-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |