Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.65 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.60 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403309 | 1.00 | S1PR1 (0.65) | S1PR1S1PR3S1PR5 | |
| SCHEMBL400581 | 1.00 | S1PR1 (0.65) | S1PR1S1PR3S1PR5 | |
| SCHEMBL4243677 | 0.94 | S1PR1 (0.56) | S1PR1S1PR3S1PR5 | |
| SCHEMBL399437 | 0.93 | S1PR1 (0.74) | S1PR1S1PR3S1PR5 | |
| SCHEMBL402419 | 0.93 | S1PR1 (0.55) | S1PR1S1PR3S1PR5 | |
| SCHEMBL401644 | 0.92 | S1PR1 (0.55) | S1PR1S1PR3S1PR5 | |
| SCHEMBL404067 | 0.92 | S1PR1 (0.55) | S1PR1S1PR3S1PR5 | |
| SCHEMBL404306 | 0.89 | S1PR1 (0.79) | S1PR1S1PR3S1PR5 | |
| SCHEMBL398415 | 0.86 | S1PR1 (0.62) | S1PR1S1PR3S1PR5 | |
| SCHEMBL402025 | 0.86 | S1PR1 (0.63) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091949-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008074821-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |