Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 15/20 | 0.71 |
| ▸ | GRIN2B | Q13224 | 15/20 | 0.71 |
| ▸ | GRIN2A | Q12879 | 13/20 | 0.61 |
| ▸ | OSBP | P22059 | 3/20 | 0.60 |
| ▸ | RORC | P51449 | 2/20 | 0.60 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.58 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720338 | 0.90 | USP2 (0.71) | GRIN1GRIN2BGRIN2AOSBPRORC | |
| SCHEMBL18374285 | 0.85 | GRIN1 (0.89) | GRIN1GRIN2BGRIN2A | |
| SCHEMBL18374103 | 0.85 | GRIN1 (0.89) | GRIN1GRIN2BGRIN2A | |
| SCHEMBL20390529 | 0.85 | GRIN1 (0.89) | GRIN1GRIN2BGRIN2A | |
| SCHEMBL4242054 | 0.85 | GRIN1 (0.65) | GRIN1GRIN2BGRIN2AOSBPRORC | |
| SCHEMBL23776659 | 0.83 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2A | |
| SCHEMBL14771153 | 0.83 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2A | |
| SCHEMBL18376887 | 0.83 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2A | |
| SCHEMBL21257789 | 0.83 | GRIN1 (0.85) | GRIN1GRIN2BGRIN2A | |
| SCHEMBL17467004 | 0.83 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193290-B2 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2012-06-05 | — | — | US | claimed |
| US-20090010984-A1 | STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2009-01-08 | — | — | US | claimed |
| US-7408014-B2 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2008-08-05 | — | — | US | claimed |
| US-20050239988-A1 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-27 | — | — | US | claimed |
| WO-2005007034-A1 | STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2005-01-27 | — | — | WO | claimed |
| US-8465542-B2 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2013-06-18 | — | — | US | disclosed |
| US-20120316295-A1 | STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2012-12-13 | — | — | US | disclosed |
| US-8193290-B2 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090010984-A1 | STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2009-01-08 | — | — | US | disclosed |
| US-7408014-B2 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2008-08-05 | — | — | US | disclosed |
| US-20050239988-A1 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-27 | — | — | US | disclosed |
| WO-2005007034-A1 | STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2005-01-27 | — | — | WO | disclosed |