Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 5/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.45 |
| ▸ | PLK1 | P53350 | 9/20 | 0.44 |
| ▸ | BRD4 | O60885 | 8/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | TAF1 | P21675 | 2/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PDXK | O00764 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245451 | 1.00 | PTK2 (0.48) | PTK2ALKPLK1BRD4RAD52 | |
| SCHEMBL4240056 | 0.93 | ALK (0.54) | PTK2ALKPLK1BRD4RAD52 | |
| SCHEMBL4240061 | 0.93 | ALK (0.54) | PTK2ALKPLK1BRD4RAD52 | |
| SCHEMBL4238616 | 0.92 | PTK2 (0.48) | PTK2ALKPLK1BRD4RAD52 | |
| SCHEMBL4238618 | 0.92 | PTK2 (0.48) | PTK2ALKPLK1BRD4RAD52 | |
| SCHEMBL4238722 | 0.92 | PTK2 (0.47) | PTK2ALKPLK1BRD4RAD52 | |
| SCHEMBL4238715 | 0.92 | PTK2 (0.47) | PTK2ALKPLK1BRD4RAD52 | |
| SCHEMBL4247616 | 0.92 | PTK2 (0.57) | PTK2PLK1BRD4RAD52AURKA | |
| SCHEMBL4247615 | 0.92 | PTK2 (0.57) | PTK2PLK1BRD4RAD52AURKA | |
| SCHEMBL4238559 | 0.89 | PTK2 (0.61) | PTK2ALKPLK1BRD4RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112524-A1 | PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |