Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.68 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.68 |
| ▸ | CDK1 | P06493 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2920679 | 0.82 | CDK2 (0.73) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL2925306 | 0.80 | CDK2 (0.79) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL2920265 | 0.80 | CDK2 (0.64) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL2916004 | 0.80 | CDK2 (0.76) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL2957863 | 0.78 | CDK2 (0.68) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL2944868 | 0.77 | CDK2 (0.70) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL2919295 | 0.76 | CDK2 (0.65) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL2920531 | 0.76 | CDK2 (0.60) | CDK2CCNA2CCNA1CDK1AURKA | |
| SCHEMBL4245671 | 0.74 | CYP1A2 (0.43) | CDK2CCNA2CCNA1CYP1A2USP2 | |
| SCHEMBL4239629 | 0.74 | CDK2 (0.60) | CDK2CCNA2CCNA1CDK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273765-B2 | Bicyclo-pyrazoles and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2012-09-25 | — | — | US | disclosed |
| US-20090221632-A1 | Bicyclo-Pyrazoles and Pharmaceutical Compositions Comprising Them | PFIZER ITALIA S.R.L. (IT) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221632-A1 | Bicyclo-Pyrazoles and Pharmaceutical Compositions Comprising Them | MAP3K20, PLK2, PRKAA1 | CDK2 70/4885CCNA2 1043/4885CCNA1 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.