Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153213 | 0.80 | KMT2A (0.52) | NPC1KMT2AGPR183THRBALDH1A1 | |
| SCHEMBL3150374 | 0.79 | DPP4 (0.52) | NPC1KMT2AGPR183THRBALDH1A1 | |
| SCHEMBL3162664 | 0.78 | KMT2A (0.47) | NPC1KMT2AHCRTR2HCRTR1GPR183 | |
| Hydrochloric Acid SCHEMBL4245600 | 0.78 | DPP4 (0.52) | NPC1KMT2AGPR183THRBALDH1A1 | |
| Hydrochloric Acid SCHEMBL4246054 | 0.78 | KMT2A (0.46) | NPC1KMT2AHCRTR2HCRTR1GPR183 | |
| SCHEMBL3157331 | 0.77 | KMT2A (0.56) | NPC1KMT2AGPR183THRBALDH1A1 | |
| SCHEMBL3150480 | 0.77 | DPP4 (0.51) | NPC1KMT2AGPR183THRBALDH1A1 | |
| SCHEMBL3158495 | 0.76 | DPP8 (0.47) | NPC1KMT2AGPR183THRBALDH1A1 | |
| SCHEMBL23023083 | 0.76 | KDM4E (0.59) | ALDH1A1KDM4ELMNARAB9A | |
| Hydrochloric Acid SCHEMBL4250477 | 0.76 | DPP4 (0.50) | NPC1KMT2AGPR183THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076325-B2 | 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2011-12-13 | — | — | US | disclosed |
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | OXER1, NR1H3, OXSR1 | NPC1 498/4885KMT2A 1570/4885HCRTR2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.