SCHEMBL4246515

SCHEMBL4246515

COCc1ccc2ccc(CN3CCC(NC(=O)c4ccc(OC)c(O)c4)CC3)cc2c1

nearest known ligand 0.72

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 14/20 0.72
DRD4 P21917 3/20 0.61
CCR3 P51677 3/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4234511 0.94 MCHR1 (0.72) MCHR1DRD4CCR3
SCHEMBL4376677 0.92 MCHR1 (0.70) MCHR1DRD4CCR3
SCHEMBL4234608 0.91 MCHR1 (0.69) MCHR1DRD4CCR3
SCHEMBL3148918 0.91 MCHR1 (0.71) MCHR1DRD4CCR3
SCHEMBL4239839 0.91 MCHR1 (0.61) MCHR1DRD4CCR3
SCHEMBL3149115 0.90 MCHR1 (0.70) MCHR1DRD4CCR3
SCHEMBL4242788 0.88 DRD4 (0.60) MCHR1DRD4CCR3
SCHEMBL3134120 0.88 MCHR1 (0.70) MCHR1DRD4CCR3
SCHEMBL3143868 0.85 MCHR1 (0.83) MCHR1DRD4CCR3
SCHEMBL3152767 0.85 MCHR1 (0.85) MCHR1DRD4CCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2098509-A1 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE Taisho Pharmaceutical Co. Ltd. (JP) 2009-09-09 EP disclosed