Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGPL1 | O95470 | 3/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.38 |
| ▸ | SMO | Q99835 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398201 | 0.90 | PTGDR2 (0.42) | SGPL1CXCR3SMOSMN1; SMN2LMNA | |
| SCHEMBL4244454 | 0.89 | SGPL1 (0.41) | SGPL1CXCR3SMOSMN1; SMN2LMNA | |
| SCHEMBL14311334 | 0.89 | SGPL1 (0.41) | SGPL1CXCR3SMOSMN1; SMN2LMNA | |
| SCHEMBL13592416 | 0.89 | SGPL1 (0.41) | SGPL1CXCR3SMOSMN1; SMN2LMNA | |
| SCHEMBL13590836 | 0.89 | SGPL1 (0.41) | SGPL1CXCR3SMOSMN1; SMN2LMNA | |
| SCHEMBL13590946 | 0.89 | MAOB (0.45) | SGPL1CXCR3SMO | |
| SCHEMBL13590947 | 0.89 | MAOB (0.45) | SGPL1CXCR3SMO | |
| SCHEMBL4249119 | 0.89 | MAOB (0.45) | SGPL1CXCR3SMO | |
| SCHEMBL13590953 | 0.88 | SGPL1 (0.40) | SGPL1CXCR3SMOSMN1; SMN2LMNA | |
| SCHEMBL4245413 | 0.88 | SGPL1 (0.40) | SGPL1CXCR3SMOSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057124-A2 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM, LLC (BM) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008011611-A2 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS | IRM LLC (BM) | 2008-01-24 | — | — | WO | disclosed |