Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 18/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.57 |
| ▸ | PRKCH | P24723 | 1/20 | 0.57 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984975 | 0.83 | PRKCQ (0.78) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL2985945 | 0.82 | PRKCQ (0.59) | PRKCQPRKCDPRKCHPRKCENPC1 | |
| SCHEMBL4190125 | 0.81 | PRKCQ (0.65) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL4187943 | 0.80 | PRKCQ (0.66) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL6994088 | 0.77 | EGFR (0.51) | PRKCQPRKCDPRKCHPRKCENPC1 | |
| SCHEMBL2984352 | 0.75 | PRKCQ (0.53) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL2980130 | 0.75 | PRKCQ (0.57) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL4454653 | 0.74 | EGFR (0.71) | — | |
| SCHEMBL2979299 | 0.74 | PRKCQ (0.75) | PRKCQPRKCDPRKCHPRKCE | |
| SCHEMBL2989600 | 0.74 | PRKCQ (0.59) | PRKCQPRKCDPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029543-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2009-03-04 | — | — | EP | claimed |
| WO-2007146376-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-12-21 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |