Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247936 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1TDP2NSD2PLCG1 | |
| SCHEMBL4248801 | 0.86 | KDM4E (0.40) | KDM4EALDH1A1NOTUMBRAFTSHR | |
| SCHEMBL4248798 | 0.86 | KDM4E (0.40) | KDM4EALDH1A1NOTUMBRAFTSHR | |
| SCHEMBL4249182 | 0.81 | KMT2A (0.51) | KDM4EALDH1A1NOTUMBRAFTSHR | |
| SCHEMBL4251469 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1NOTUMBRAFTSHR | |
| SCHEMBL4247900 | 0.79 | HPGD (0.44) | KDM4EALDH1A1TDP2NSD2PLCG1 | |
| SCHEMBL4247898 | 0.79 | HPGD (0.44) | KDM4EALDH1A1TDP2NSD2PLCG1 | |
| SCHEMBL4249080 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1NOTUMBRAFTSHR | |
| SCHEMBL4251287 | 0.78 | KMT2A (0.39) | KDM4EALDH1A1NSD2SMN1; SMN2MEN1 | |
| SCHEMBL4251290 | 0.78 | KMT2A (0.39) | KDM4EALDH1A1NSD2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |