Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9937267 | 0.85 | HTR2C (0.44) | HTR2CPIK3CAARPIK3R1SMN1; SMN2 | |
| SCHEMBL1284337 | 0.84 | PIK3CA (0.46) | HTR2CPIK3CAARPIK3R1SMN1; SMN2 | |
| SCHEMBL4439753 | 0.80 | HTR2C (0.45) | HTR2CPIK3CAARPIK3R1SMN1; SMN2 | |
| SCHEMBL1181305 | 0.80 | PIK3CA (0.60) | HTR2CPIK3CAARPIK3R1SMN1; SMN2 | |
| SCHEMBL9937571 | 0.77 | HTR2C (0.43) | HTR2CPIK3CAARPIK3R1SMN1; SMN2 | |
| SCHEMBL4435238 | 0.75 | HTR2C (0.74) | HTR2CPIK3CAARSMN1; SMN2PIK3CD | |
| SCHEMBL1181712 | 0.73 | PIK3CA (0.45) | PIK3CAPIK3R1SMN1; SMN2PIK3CDALOX15 | |
| SCHEMBL1858722 | 0.73 | HTR2C (0.47) | HTR2CPIK3CAARPIK3R1SMN1; SMN2 | |
| SCHEMBL4435243 | 0.73 | HTR2C (0.53) | HTR2CPIK3CAPIK3R1SMN1; SMN2PIK3CD | |
| SCHEMBL190498 | 0.73 | PIK3CA (0.56) | PIK3CAPIK3R1SMN1; SMN2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |