Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479565 | 1.00 | BACE1 (0.54) | BACE1PKM | |
| SCHEMBL4249249 | 1.00 | BACE1 (0.54) | BACE1PKM | |
| SCHEMBL3479312 | 0.94 | BACE1 (0.60) | BACE1 | |
| SCHEMBL2627859 | 0.93 | BACE1 (0.58) | BACE1 | |
| SCHEMBL8196366 | 0.90 | BACE1 (0.56) | BACE1 | |
| Trifluoroacetic Acid SCHEMBL3479614 | 0.90 | BACE1 (0.54) | BACE1 | |
| SCHEMBL3479507 | 0.88 | BACE1 (0.54) | BACE1 | |
| SCHEMBL3479550 | 0.88 | BACE1 (0.54) | BACE1 | |
| SCHEMBL3479484 | 0.86 | BACE1 (0.56) | BACE1 | |
| SCHEMBL3479546 | 0.85 | BACE1 (0.53) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063889-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008030412-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | claimed |