Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 15/20 | 0.67 |
| ▸ | RPS6KA5 | O75582 | 11/20 | 0.67 |
| ▸ | RPS6KA1 | Q15418 | 10/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.66 |
| ▸ | AKT2 | P31751 | 9/20 | 0.66 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.66 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | SMC2 | O95347 | 1/20 | 0.47 |
| ▸ | LATS1 | O95835 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062531 | 0.90 | AKT1 (0.60) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| SCHEMBL4066468 | 0.90 | AKT1 (0.63) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| SCHEMBL4066128 | 0.89 | AKT1 (0.69) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| SCHEMBL4241089 | 0.88 | AKT1 (0.72) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| SCHEMBL4062696 | 0.86 | AKT1 (0.68) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| Trifluoroacetic Acid SCHEMBL5066233 | 0.84 | AKT1 (0.62) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| SCHEMBL4073397 | 0.84 | AKT1 (0.60) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| Trifluoroacetic Acid SCHEMBL5066184 | 0.84 | AKT1 (0.61) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| SCHEMBL4071038 | 0.83 | AKT1 (0.73) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 | |
| SCHEMBL4071365 | 0.83 | AKT1 (0.68) | AKT1RPS6KA5RPS6KA1ROCK1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | claimed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | claimed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | claimed |
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | AKT1 5/4885RPS6KA5 156/4885RPS6KA1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.