Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Athraquinones A. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.83 |
| ▸ | MEN1 | O00255 | 7/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.83 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.83 |
| ▸ | MAOA | P21397 | 4/20 | 0.83 |
| ▸ | HPGD | P15428 | 4/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.83 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.83 |
| ▸ | RECQL | P46063 | 3/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.83 |
| ▸ | BCL2 | P10415 | 3/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.83 |
| ▸ | APEX1 | P27695 | 2/20 | 0.83 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.83 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.83 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.83 |
| ▸ | ELANE | P08246 | 8/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Athraquinones A SCHEMBL29373337 | 0.91 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL4972786 | 0.91 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL18614 | 0.91 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL21114402 | 0.91 | MAPT (1.00) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL11805858 | 0.89 | MAPT (0.96) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL22471867 | 0.89 | MAPT (0.96) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL7839563 | 0.89 | MAPT (0.96) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL3228431 | 0.89 | MAPT (0.96) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL30498009 | 0.89 | MAPT (0.96) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| Athraquinones A SCHEMBL28033070 | 0.89 | MAPT (0.96) | MAPTMEN1KMT2AALDH1A1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111663156-A | Brightener for VCP electroplating and preparation method thereof | 惠州市腾达宇科技有限公司 | 2020-09-15 | — | — | CN | claimed |
| CN-110453254-A | A kind of pulse plating brightener and preparation method thereof | GUANGZHOU HAOYUE NEW MATERIAL TECH CO LTD | 2019-11-15 | — | — | CN | claimed |
| CN-111663156-A | Brightener for VCP electroplating and preparation method thereof | 惠州市腾达宇科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| CN-110453254-A | A kind of pulse plating brightener and preparation method thereof | GUANGZHOU HAOYUE NEW MATERIAL TECH CO LTD | 2019-11-15 | — | — | CN | disclosed |
| CN-110453254-A | A kind of pulse plating brightener and preparation method thereof | GUANGZHOU HAOYUE NEW MATERIAL TECH CO LTD | 2019-11-15 | — | — | CN | disclosed |
| WO-2009009601-A1 | METHOD OF PROCESSING MILK | RODRIGUEZ ALEXANDER (US) | 2009-01-15 | — | — | WO | disclosed |