Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.64 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.64 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.64 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.64 |
| ▸ | CDK2 | P24941 | 15/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.53 |
| ▸ | CDK9 | P50750 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.52 |
| ▸ | CDK4 | P11802 | 2/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | CCND3 | P30281 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4248257 | 0.85 | CDK4 (0.56) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL13878944 | 0.83 | CDK2 (0.52) | CDK1CDK5CDK2CCNE1CCNE2 | |
| SCHEMBL4251077 | 0.83 | KCNH2 (0.47) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL13891512 | 0.82 | CDK2 (0.51) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL4462397 | 0.81 | CDK1 (0.55) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL28773006 | 0.81 | CDK2 (0.50) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| Hydrochloric Acid SCHEMBL4251765 | 0.80 | CDK1 (0.54) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL4246808 | 0.80 | CDK2 (0.59) | CDK1CDK2KCNH2GSK3AGSK3B | |
| SCHEMBL28776432 | 0.80 | CDK2 (0.49) | CDK1CCNB1CDK5CDK5R1CCNB2 | |
| SCHEMBL6595895 | 0.80 | CDK2 (0.81) | CDK1CCNB1CDK5CDK5R1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105252-A1 | Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | US | claimed |
| CN-101326179-A | New pyrimidine derivatives and their use in therapy as well as the use of pyrimidine derivatives in the manufacture of a medicament for prevention and/or treatment of alzheimer's disease | ASTRAZENECA AB (SE) | 2008-12-17 | — | — | CN | claimed |
| US-20090105252-A1 | Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105252-A1 | Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | US | disclosed |
| CN-101326179-A | New pyrimidine derivatives and their use in therapy as well as the use of pyrimidine derivatives in the manufacture of a medicament for prevention and/or treatment of alzheimer's disease | ASTRAZENECA AB (SE) | 2008-12-17 | — | — | CN | disclosed |
| EP-1945628-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007040440-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER’S DISEASE | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105252-A1 | Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease | DPYD, TYMS, TYMP | CDK1 253/4885CCNB1 114/4885CDK5 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.