Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | FCER2 | P06734 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | TPH1 | P17752 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936746 | 0.83 | AKT1 (0.48) | AKT1CYP1A2PDGFRBPDGFRAPDE10A | |
| SCHEMBL22401385 | 0.80 | HTR2A (0.57) | AKT1CYP1A2PDGFRBPDGFRAPDE10A | |
| SCHEMBL23009533 | 0.80 | HTR2A (0.57) | AKT1CYP1A2PDGFRBPDGFRAPDE10A | |
| SCHEMBL3638034 | 0.77 | DHODH (0.49) | CYP1A2PDGFRBPDGFRAPDE10AKDM1A | |
| SCHEMBL28270504 | 0.77 | CYP1A2 (0.46) | AKT1CYP1A2PDGFRBPDGFRAPDE10A | |
| SCHEMBL263918 | 0.77 | CYP1A2 (0.52) | CYP1A2PDGFRBPDGFRAPDE10AKDM1A | |
| SCHEMBL30101236 | 0.77 | CYP1A2 (0.52) | CYP1A2PDGFRBPDGFRAPDE10AKDM1A | |
| SCHEMBL2267933 | 0.76 | AKT1 (0.45) | AKT1CYP1A2PDGFRBPDGFRAPDE10A | |
| SCHEMBL2267925 | 0.76 | CYP1A2 (0.44) | AKT1CYP1A2PDGFRBPDGFRAPDE10A | |
| SCHEMBL2267928 | 0.76 | CYP1A2 (0.44) | AKT1CYP1A2PDGFRBPDGFRAPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081917-A2 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | Abbott Laboratories (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008027932-A2 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2008-03-06 | — | — | WO | disclosed |