Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2102540 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL1196006 | 0.84 | MEN1 (0.51) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL1196005 | 0.84 | MEN1 (0.51) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| Hydrochloric Acid SCHEMBL8582025 | 0.83 | MEN1 (0.50) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL12990594 | 0.83 | HDAC1 (0.52) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL2104310 | 0.82 | MEN1 (0.52) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3892412 | 0.81 | CRBN (0.51) | PLD1KCNH2DDB1CRBN | |
| SCHEMBL6247721 | 0.81 | BACE1 (0.56) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL25233171 | 0.80 | HDAC1 (0.48) | SMN1; SMN2NPC1RAB9AGAAMAPK1 | |
| SCHEMBL10263318 | 0.78 | MEN1 (0.50) | SMN1; SMN2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020470-A2 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-02-12 | — | — | WO | disclosed |