Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 6/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645497 | 1.00 | HTR2A (0.50) | HTR2AHTR2CHTR2BGRIA4TAAR1 | |
| SCHEMBL1645763 | 0.96 | HTR2A (0.50) | HTR2AHTR2CHTR2BGRIA4TAAR1 | |
| SCHEMBL1645762 | 0.96 | HTR2A (0.50) | HTR2AHTR2CHTR2BGRIA4TAAR1 | |
| SCHEMBL3717272 | 0.81 | GRIA4 (0.44) | GRIA4KDM1ANOS3NOS1NOS2 | |
| SCHEMBL3717270 | 0.81 | GRIA4 (0.44) | GRIA4KDM1ANOS3NOS1NOS2 | |
| SCHEMBL1643845 | 0.81 | GRIA4 (0.44) | GRIA4KDM1ANOS3NOS1NOS2 | |
| SCHEMBL3719897 | 0.81 | GRIA4 (0.44) | GRIA4KDM1ANOS3NOS1NOS2 | |
| SCHEMBL3422301 | 0.81 | HTR2C (0.61) | HTR2AHTR2CHTR2BTAAR1KDM1A | |
| SCHEMBL6998583 | 0.81 | HTR2C (0.61) | HTR2AHTR2CHTR2BTAAR1KDM1A | |
| SCHEMBL3419759 | 0.81 | HTR2C (0.61) | HTR2AHTR2CHTR2BTAAR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833782-B1 | CYCLOALKYLAMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | EP | disclosed |
| EP-1246797-B1 | CYCLOPENTYL SULFONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |