Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | DBH | P09172 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609205 | 0.87 | HDAC8 (0.71) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4251712 | 0.84 | HDAC6 (0.54) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4254173 | 0.83 | HDAC6 (0.75) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4253924 | 0.82 | HDAC8 (0.55) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4254164 | 0.81 | HDAC6 (0.61) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4247700 | 0.81 | HDAC8 (0.58) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4254015 | 0.79 | HDAC8 (0.56) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4251224 | 0.79 | EPHX2 (0.46) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL1608403 | 0.79 | HDAC8 (0.71) | HDAC8HDAC6HDAC1HDAC2HDAC10 | |
| SCHEMBL4251128 | 0.78 | HDAC8 (0.53) | HDAC8HDAC6HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | HDAC8 2/4885HDAC6 11/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.