Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 4/20 | 0.35 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4247360 | 0.88 | CHRM2 (0.45) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4247516 | 0.87 | ABCB1 (0.40) | MAPTKMT2AMEN1CHRM2HTR1A | |
| SCHEMBL4247539 | 0.85 | ESR2 (0.42) | MAPTKMT2ASMN1; SMN2ALDH1A1CHRM2 | |
| SCHEMBL4250522 | 0.84 | KMT2A (0.41) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4248373 | 0.82 | KMT2A (0.36) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4243341 | 0.80 | MAPT (0.44) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4247356 | 0.80 | ESR2 (0.42) | MAPTKMT2ASMN1; SMN2ALDH1A1CHRM2 | |
| SCHEMBL4253490 | 0.80 | MAPT (0.41) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3155094 | 0.77 | CHRM2 (0.47) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4249161 | 0.76 | CHRM2 (0.46) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076325-B2 | 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2011-12-13 | — | — | US | disclosed |
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | OXER1, NR1H3, OXSR1 | MAPT 2717/4885KMT2A 1570/4885MEN1 2079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.