Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252562 | 0.97 | SMN1; SMN2 (0.66) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL4253319 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL4253872 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL4250776 | 0.90 | SMN1; SMN2 (0.66) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL443025 | 0.88 | SMN1; SMN2 (0.74) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL4253893 | 0.88 | SMN1; SMN2 (0.74) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL4258261 | 0.88 | KMT2A (0.55) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL445225 | 0.85 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL4255664 | 0.85 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AMAPTGAARAB9A | |
| SCHEMBL445226 | 0.85 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AMAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | SMN1; SMN2 3469/4885KMT2A 94/4885MAPT 2673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.