Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.58 |
| ▸ | PDE4A | P27815 | 6/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | PDE5A | O76074 | 5/20 | 0.54 |
| ▸ | PDE1A | P54750 | 2/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254116 | 1.00 | PDE4D (0.58) | PDE4DPDE4APDE4BPDE4CHDAC1 | |
| SCHEMBL4267394 | 0.91 | HDAC1 (0.70) | PDE4DPDE4APDE4BPDE4CHDAC1 | |
| SCHEMBL4267381 | 0.91 | HDAC1 (0.70) | PDE4DPDE4APDE4BPDE4CHDAC1 | |
| SCHEMBL4256767 | 0.80 | HDAC1 (0.82) | HDAC1HDAC2 | |
| SCHEMBL4256762 | 0.80 | HDAC1 (0.82) | HDAC1HDAC2 | |
| SCHEMBL7423277 | 0.77 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL27627999 | 0.76 | HDAC1 (0.60) | PDE4DPDE4APDE4BPDE4CHDAC1 | |
| SCHEMBL7340175 | 0.75 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7334418 | 0.74 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL4260533 | 0.72 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-01-22 | — | — | US | disclosed |
| US-7282608-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2007-10-16 | — | — | US | disclosed |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2006-01-26 | — | — | US | disclosed |
| EP-1572203-A1 | SUBSTITUTED 4-ALKOXYOXAZOL DERIVATIVES AS PPAR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | disclosed |
| EP-1551795-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004041275-A1 | SUBSTITUTED 4-ALKOXYOXAZOL DERIVATIVES AS PPAR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-21 | — | — | WO | disclosed |
| WO-2004035525-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC6 | PDE4D 2951/4885PDE4A 2010/4885PDE4B 1989/4885 |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | HDAC1, AADAC, HDAC11 | PDE4D 3093/4885PDE4A 2666/4885PDE4B 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.