Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.72 |
| ▸ | NAMPT | P43490 | 4/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | F3 | P13726 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13949683 | 1.00 | HDAC1 (0.72) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL13949680 | 0.91 | HDAC1 (0.62) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL4262372 | 0.91 | HDAC1 (0.62) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL4260272 | 0.87 | HDAC1 (0.62) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL1071012 | 0.84 | HDAC1 (0.78) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL31720922 | 0.84 | HDAC1 (0.78) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL4255531 | 0.84 | HDAC1 (1.00) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL4255532 | 0.84 | HDAC1 (1.00) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL13949674 | 0.83 | HDAC1 (0.71) | HDAC1NAMPTHDAC2HDAC3HDAC11 | |
| SCHEMBL4269528 | 0.82 | HDAC1 (0.82) | HDAC1NAMPTHDAC2HDAC3HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-01-22 | — | — | US | disclosed |
| US-7282608-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2007-10-16 | — | — | US | disclosed |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC6 | HDAC1 1/4885NAMPT 214/4885HDAC2 6/4885 |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | HDAC1, AADAC, HDAC11 | HDAC1 1/4885NAMPT 351/4885HDAC2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.