Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.44 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.44 |
| ▸ | NDUFAB1 | O14561 | 1/20 | 0.44 |
| ▸ | NDUFA1 | O15239 | 1/20 | 0.44 |
| ▸ | NDUFS4 | O43181 | 1/20 | 0.44 |
| ▸ | NDUFB5 | O43674 | 1/20 | 0.44 |
| ▸ | NDUFB3 | O43676 | 1/20 | 0.44 |
| ▸ | NDUFC1 | O43677 | 1/20 | 0.44 |
| ▸ | NDUFA2 | O43678 | 1/20 | 0.44 |
| ▸ | NDUFS5 | O43920 | 1/20 | 0.44 |
| ▸ | NDUFS7 | O75251 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250910 | 0.97 | KMT2A (0.52) | SMN1; SMN2RAB9AKMT2AALDH1A1MMP1 | |
| SCHEMBL445294 | 0.89 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9AKMT2AALDH1A1MMP1 | |
| SCHEMBL445691 | 0.86 | KMT2A (0.54) | SMN1; SMN2RAB9AKMT2AALDH1A1MMP1 | |
| SCHEMBL4252914 | 0.76 | HDAC1 (0.52) | SMN1; SMN2RAB9AMAPTHDAC3HDAC4 | |
| SCHEMBL4253893 | 0.76 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9AKMT2AALDH1A1MMP1 | |
| SCHEMBL4253316 | 0.76 | HPGD (0.45) | SMN1; SMN2RAB9AALDH1A1POLBHDAC3 | |
| SCHEMBL4254244 | 0.76 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL4254137 | 0.74 | SMPD1 (0.47) | SMN1; SMN2RAB9AKMT2AALDH1A1POLB | |
| SCHEMBL14918377 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AKMT2AALDH1A1MMP1 | |
| SCHEMBL14918376 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AKMT2AALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | SMN1; SMN2 3469/4885RAB9A 3763/4885KMT2A 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.