Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479639 | 1.00 | BACE1 (0.50) | BACE1SCDIL4I1 | |
| SCHEMBL3479398 | 0.92 | BACE1 (0.47) | BACE1 | |
| SCHEMBL3479522 | 0.91 | BACE1 (0.52) | BACE1 | |
| SCHEMBL4253964 | 0.91 | BACE1 (0.52) | BACE1 | |
| SCHEMBL3479493 | 0.88 | BACE1 (0.49) | BACE1 | |
| SCHEMBL3479469 | 0.88 | BACE1 (0.53) | BACE1 | |
| SCHEMBL3479492 | 0.87 | BACE1 (0.57) | BACE1 | |
| SCHEMBL3479513 | 0.87 | BACE1 (0.51) | BACE1 | |
| SCHEMBL3479440 | 0.86 | BACE1 (0.52) | BACE1 | |
| SCHEMBL3479541 | 0.86 | BACE1 (0.52) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063889-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008030412-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | claimed |