Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 5/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257160 | 1.00 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1OPRM1OPRD1OPRK1 | |
| SCHEMBL4258000 | 0.88 | ESR1 (0.40) | OPRM1OPRD1OPRK1ESR1SLC6A2 | |
| SCHEMBL4253232 | 0.86 | ESR1 (0.39) | OPRM1OPRD1ESR1SLC6A2SLC6A3 | |
| SCHEMBL4255138 | 0.83 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1OPRM1OPRD1OPRK1 | |
| SCHEMBL4252407 | 0.82 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1OPRM1OPRD1OPRK1 | |
| SCHEMBL4255132 | 0.81 | ESR1 (0.39) | HSP90AA1HSP90AB1OPRM1OPRD1OPRK1 | |
| SCHEMBL4257163 | 0.81 | ESR1 (0.39) | HSP90AA1HSP90AB1OPRM1OPRD1OPRK1 | |
| SCHEMBL4261805 | 0.79 | ESR1 (0.36) | ESR1SLC6A2SLC6A3PGRCHRM2 | |
| SCHEMBL4254768 | 0.79 | ESR1 (0.39) | HSP90AB1ESR1SLC6A2SLC6A3PGR | |
| SCHEMBL3468205 | 0.79 | ESR1 (0.51) | ESR1ESR2CA2LMNARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569601-B2 | Cycloalkylidene compounds as modulators of estrogen receptor | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |
| US-20070213348-A1 | Chemical Compounds | BRITTON JONATHAN E | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213348-A1 | Chemical Compounds | GPER1, ESR2, ESR1 | HSP90AA1 2233/4885HSP90AB1 1255/4885OPRM1 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.