Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 4/20 | 0.62 |
| ▸ | CASP7 | P55210 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325547 | 0.89 | KDM4E (0.72) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL3323430 | 0.85 | KDM4E (0.76) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL3323749 | 0.85 | KDM4E (0.86) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL12135798 | 0.85 | KDM4E (1.00) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL3001267 | 0.84 | KDM4E (0.70) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL3323056 | 0.82 | KDM4E (0.74) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL15765866 | 0.82 | KDM4E (0.72) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL3325420 | 0.82 | KDM4E (0.63) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL3323888 | 0.82 | KDM4E (0.68) | KDM4EGAAHTTALDH1A1HSD17B10 | |
| SCHEMBL3320549 | 0.82 | KDM4E (0.77) | KDM4EGAAHTTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |