Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884099 | 0.89 | HDAC3 (0.66) | HDAC3HDAC8HDAC6ALDH1A1HPGD | |
| SCHEMBL4256646 | 0.89 | HDAC3 (0.51) | HDAC3HDAC8HDAC6ALDH1A1HPGD | |
| SCHEMBL8291858 | 0.88 | HDAC3 (0.53) | HDAC3HDAC8HDAC6ALDH1A1HPGD | |
| SCHEMBL1885459 | 0.78 | HDAC1 (0.62) | HDAC3HDAC8HDAC6ALDH1A1HPGD | |
| SCHEMBL1886090 | 0.78 | HDAC1 (0.68) | HDAC3HDAC8HDAC6HDAC1 | |
| SCHEMBL1891467 | 0.77 | HDAC1 (0.57) | HDAC3HDAC8HDAC6ALDH1A1HDAC1 | |
| SCHEMBL1888087 | 0.76 | HDAC1 (0.56) | HDAC3HDAC8HDAC6ALDH1A1HDAC1 | |
| SCHEMBL1887003 | 0.76 | HDAC1 (0.56) | HDAC3HDAC8HDAC6HPGDLMNA | |
| SCHEMBL1885946 | 0.76 | HDAC1 (0.59) | HDAC3HDAC8HDAC6ALDH1A1LMNA | |
| SCHEMBL12078791 | 0.75 | HDAC3 (0.78) | HDAC3HDAC8HDAC6ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677731-A4 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1677731-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | Aton Pharma, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005034880-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA, INC. (US) | 2005-04-21 | — | — | WO | disclosed |