Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.55 |
| ▸ | MTOR | P42345 | 7/20 | 0.52 |
| ▸ | ATR | Q13535 | 12/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 12/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 12/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 11/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3080008 | 0.85 | PIK3CA (0.60) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3077731 | 0.84 | PIK3CA (0.52) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3089721 | 0.83 | PIK3CA (0.60) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3088132 | 0.82 | PIK3CA (0.50) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3597852 | 0.80 | PIK3CA (0.53) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3598283 | 0.80 | PIK3CA (0.58) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3597091 | 0.79 | PIK3CA (0.71) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3592490 | 0.79 | PIK3CA (0.69) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3594238 | 0.79 | PIK3CA (0.56) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3591063 | 0.78 | PIK3CA (0.56) | PIK3CAPIK3CDMTORATRPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |