Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.66 |
| ▸ | BRAF | P15056 | 7/20 | 0.64 |
| ▸ | RAF1 | P04049 | 5/20 | 0.64 |
| ▸ | LYN | P07948 | 4/20 | 0.64 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | HCK | P08631 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 3/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253241 | 0.89 | BRAF (0.55) | CSF1RBRAFRAF1LYNLCK | |
| SCHEMBL4256187 | 0.89 | BRAF (0.63) | CSF1RBRAFRAF1LYNLCK | |
| SCHEMBL4829508 | 0.89 | CSF1R (0.68) | CSF1RBRAFRAF1MAPK14 | |
| SCHEMBL4250376 | 0.88 | CSF1R (0.67) | CSF1RBRAFRAF1LYNLCK | |
| SCHEMBL4257827 | 0.88 | CSF1R (0.65) | CSF1RBRAFRAF1LYNLCK | |
| SCHEMBL3585041 | 0.88 | CSF1R (0.66) | CSF1RBRAFRAF1LYNLCK | |
| SCHEMBL10106132 | 0.88 | CSF1R (0.66) | CSF1RBRAFRAF1LYNLCK | |
| SCHEMBL25534482 | 0.84 | CSF1R (0.70) | CSF1RBRAFRAF1LYNLCK | |
| SCHEMBL1358527 | 0.83 | HDAC3 (0.58) | CSF1RBRAFLCKKDRSRC | |
| SCHEMBL4823998 | 0.81 | BRAF (0.68) | CSF1RBRAFRAF1LYNLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-23 | — | — | US | claimed |
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | ABL1, BCR, PDGFRB | CSF1R 891/4885BRAF 8/4885RAF1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.