Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 12/20 | 0.47 |
| ▸ | ACACA | Q13085 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260315 | 0.97 | ACACB (0.48) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4261998 | 0.93 | ACACB (0.50) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4261368 | 0.90 | ACACB (0.49) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4504972 | 0.88 | ACACB (0.49) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4258719 | 0.87 | ACACB (0.57) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4509645 | 0.87 | ACACB (0.47) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4521164 | 0.87 | ACACB (0.49) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4496352 | 0.86 | ACACB (0.56) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL4505000 | 0.85 | ACACB (0.55) | ACACBACACA | |
| SCHEMBL4511126 | 0.84 | HDAC3 (0.56) | ACACBACACAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097420-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | Pfizer Products Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008065508-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |