Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.35 |
| ▸ | PLK1 | P53350 | 4/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200557 | 1.00 | IGF1R (0.35) | IGF1RPLK1ADRB2ADRB1CYP2D6 | |
| SCHEMBL2198357 | 1.00 | IGF1R (0.35) | IGF1RPLK1ADRB2ADRB1CYP2D6 | |
| SCHEMBL2197154 | 1.00 | IGF1R (0.35) | IGF1RPLK1ADRB2ADRB1CYP2D6 | |
| SCHEMBL2198544 | 0.91 | PLK1 (0.35) | IGF1RPLK1HTR1AADRA2AADRA2B | |
| SCHEMBL2198979 | 0.90 | IGF1R (0.38) | IGF1RADRB2ADRB1CYP2D6NFKB1 | |
| SCHEMBL2196563 | 0.90 | PLK1 (0.34) | IGF1RPLK1HTR1AADRA2AADRA2B | |
| SCHEMBL19951497 | 0.90 | PLK1 (0.34) | IGF1RPLK1HTR1AADRA2AADRA2B | |
| SCHEMBL4272407 | 0.90 | PLK1 (0.34) | IGF1RPLK1HTR1AADRA2AADRA2B | |
| SCHEMBL4264314 | 0.90 | PLK1 (0.34) | IGF1RPLK1HTR1AADRA2AADRA2B | |
| SCHEMBL2198389 | 0.90 | PLK1 (0.34) | IGF1RPLK1HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116543-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVE AS PLK1 INHIBITOR | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-11-11 | — | — | EP | disclosed |