Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 7/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888902 | 0.94 | CLK1 (0.50) | CLK1DYRK1APTPN2RAB9AMAPT | |
| SCHEMBL1000816 | 0.83 | PTPN2 (0.49) | CLK1DYRK1APTPN2RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL6983330 | 0.82 | PTPN2 (0.48) | CLK1DYRK1APTPN2RAB9AMAPT | |
| SCHEMBL3187716 | 0.76 | PTPN2 (0.47) | CLK1DYRK1APTPN2RAB9AMAPT | |
| SCHEMBL1890495 | 0.76 | HDAC1 (0.62) | CLK1HDAC1HDAC3HDAC2 | |
| SCHEMBL1885929 | 0.74 | CLK1 (0.46) | CLK1DYRK1APTPN2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2822973 | 0.73 | PTPN2 (0.49) | PTPN2RAB9AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL21417393 | 0.72 | PTPN2 (0.50) | CLK1DYRK1APTPN2RAB9AMAPT | |
| SCHEMBL29913871 | 0.72 | BCL2L1 (0.57) | DYRK1APTPN2RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4405770 | 0.72 | BCL2L1 (0.57) | DYRK1APTPN2RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677731-A4 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1677731-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | Aton Pharma, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005034880-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA, INC. (US) | 2005-04-21 | — | — | WO | disclosed |