Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27661524 | 0.82 | KDR (0.54) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL27681104 | 0.81 | KDR (0.52) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3922131 | 0.80 | KDR (0.51) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3922144 | 0.80 | KDR (0.51) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3920189 | 0.80 | KDR (0.51) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3920188 | 0.80 | KDR (0.51) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3922896 | 0.79 | KDR (0.53) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3922887 | 0.79 | KDR (0.53) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3922504 | 0.78 | KDR (0.49) | KDRCHEK1FGFR1AURKAAURKB | |
| SCHEMBL3922501 | 0.78 | KDR (0.49) | KDRCHEK1FGFR1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732938-B1 | ORGANOPHOSPHOROUS INDAZOLE DERIVATIVES AND USE THEREOF AS PROTEIN KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-05-06 | — | — | EP | disclosed |