Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.92 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.92 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | HLA-A | P04439 | 1/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxazosin SCHEMBL29359735 | 1.00 | KMT2A (1.00) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL29429099 | 1.00 | KMT2A (1.00) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL2945426 | 1.00 | KMT2A (1.00) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL4725733 | 1.00 | KMT2A (1.00) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL158685 | 1.00 | KMT2A (1.00) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL17652050 | 0.98 | KMT2A (0.95) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL10549641 | 0.97 | KMT2A (0.94) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL10416953 | 0.96 | KMT2A (0.93) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL1648487 | 0.96 | KMT2A (1.00) | KMT2ACYP3A4HSD17B10KDM4EMEN1 | |
| Doxazosin SCHEMBL29711371 | 0.96 | KMT2A (1.00) | KMT2ACYP3A4HSD17B10KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9433 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12590181-B2 | Hydrophobically-modified associative thickener polymers process for the preparation and uses thereof | HERCULES LLC (US) | 2026-03-31 | — | — | US | claimed |
| EP-4192923-B1 | HYDROPHOBICALLY-MODIFIED ASSOCIATIVE THICKENER POLYMERS PROCESS FOR THE PREPARATION AND USES THEREOF | HERCULES LLC (US) | 2025-10-29 | — | — | EP | claimed |
| US-20250302887-A1 | AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE | AOBIOME LLC (US) | 2025-10-02 | — | — | US | claimed |
| WO-2025131019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF INHIBIN SUBUNIT BETA E (INHBE) | SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) | 2025-06-26 | — | — | WO | claimed |
| CN-119955108-A | Nonionic aqueous hydroxyl-containing polyacrylate secondary dispersion, and preparation method and application thereof | 上海华谊涂料有限公司 | 2025-05-09 | — | — | CN | claimed |
| CN-119875714-A | Synthetic ester refrigeration equipment lubricant | 刚和石油(营口)有限公司 | 2025-04-25 | — | — | CN | claimed |
| US-20250090602-A1 | AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE | AOBIOME LLC (US) | 2025-03-20 | — | — | US | claimed |
| CN-116324124-B | Hydrophobically modified associative thickener polymer and preparation method and application thereof | 赫尔克里士有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-116324123-B | Hydrophobically modified associative thickener polymer and preparation method and application thereof | 赫尔克里士有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119486719-A | Osmotic pump controlled release preparation, osmotic pump controlled release composition, preparation method and application | 中国科学院上海药物研究所 | 2025-02-18 | — | — | CN | claimed |
| WO-2000059951-A1 | CROSS-LINKED MICROPARTICLES, METHOD FOR THE PRODUCTION AND USE THEREOF | CRAY VALLEY S.A. (FR) | 2000-10-12 | — | — | WO | claimed |
| WO-2000059953-A1 | THERMOSETTING RESIN COMPOSITIONS COMPRISING CROSS-LINKED REACTIVE MICROPARTICLES WITH IMPROVED MECHANICAL STRENGTH | CRAY VALLEY SA (FR) | 2000-10-12 | — | — | WO | claimed |
| US-6130218-A | Polymorphic form of doxazosin mesylate (Form I) | HEUMANN PHARMA GMBH (DE) | 2000-10-10 | — | — | US | claimed |
| EP-1037616-A2 | COMBINATION OF ALPHA-ADRENERGIC BLOCKERS AND CGMP LEVELS-ELEVATING COMPOUNDS EFFECTIVE FOR THE TREATMENT OF IMPOTENCE | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1999030697-A2 | COMBINATION EFFECTIVE FOR THE TREATMENT OF IMPOTENCE | PFIZER PRODUCTS INC. (US) | 1999-06-24 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0848001-A1 | Crystalline form of the doxazosin mesylate and process for its production | Alfa Chemicals Italiana S.r.l. (IT) | 1998-06-17 | — | — | EP | claimed |
| EP-0334465-B1 | Dosage form for dispensing drug for human therapy | ALZA CORP (US) | 1993-10-27 | — | — | EP | claimed |
| EP-0334465-A1 | Dosage form for dispensing drug for human therapy | ALZA CORPORATION (US) | 1989-09-27 | — | — | EP | claimed |
| US-4837111-A | DOXAZOIN; OSMOTIC DEVICE | ALZA CORPORATION (US) | 1989-06-06 | — | — | US | claimed |