Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31581118 | 1.00 | MCHR1 (0.42) | MCHR1BRD4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL3112003 | 0.98 | SLC6A2 (0.41) | MCHR1BRD4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL4844 | 0.95 | SLC6A2 (0.41) | MCHR1BRD4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL19437904 | 0.91 | SLC6A2 (0.43) | MCHR1BRD4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL31546857 | 0.91 | SLC6A2 (0.43) | MCHR1BRD4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL4503320 | 0.83 | HRH1 (0.47) | BRD4SLC6A2SLC6A4KCNH2HTR7 | |
| SCHEMBL12949688 | 0.82 | PDGFRB (0.48) | MCHR1BRD4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL31304348 | 0.80 | CHRM2 (0.43) | SLC6A2KCNH2HTR7 | |
| SCHEMBL12093187 | 0.79 | SLC6A4 (0.44) | SLC6A2SLC6A4KCNH2HTR7 | |
| SCHEMBL911339 | 0.79 | SLC6A4 (0.58) | SLC6A2SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796677-B2 | Amide compound and pharmaceutical comprising same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2017-10-24 | — | — | US | disclosed |
| EP-2483251-B1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-3081556-A1 | AMIDE COMPOUND AND PHARMACEUTICAL COMPRISING SAME | Japan Science and Technology Agency (JP) | 2016-10-19 | — | — | EP | disclosed |
| US-20160297764-A1 | AMIDE COMPOUND AND PHARMACEUTICAL COMPRISING SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2016-10-13 | — | — | US | disclosed |
| US-8664220-B2 | Polycyclic compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS, INC. (US) | 2014-03-04 | — | — | US | disclosed |
| US-20130072490-A1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC. (US) | 2013-03-21 | — | — | US | disclosed |
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297764-A1 | AMIDE COMPOUND AND PHARMACEUTICAL COMPRISING SAME | APP, BACE1, APBA1 | MCHR1 3162/4885BRD4 992/4885SLC6A2 1421/4885 |
| US-20130072490-A1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR4 | MCHR1 535/4885BRD4 1103/4885SLC6A2 4116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.