Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 14/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4527427 | 0.92 | PIK3CB (0.55) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4264279 | 0.88 | PIK3CB (0.43) | PIK3CBPIK3CAPIK3CDPIK3CGJAK2 | |
| SCHEMBL4780939 | 0.88 | PIK3CB (0.56) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4534245 | 0.84 | PIK3CB (0.62) | PIK3CBPIK3CAPIK3CDPIK3CGJAK2 | |
| SCHEMBL3987144 | 0.82 | PIK3CB (0.63) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL4277073 | 0.77 | PIK3CB (0.48) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL3589159 | 0.77 | PIK3CB (0.61) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4523399 | 0.77 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL3987588 | 0.76 | PIK3CB (0.60) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL4528340 | 0.76 | PIK3CB (0.56) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061784-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-27 | — | — | EP | claimed |
| WO-2008032086-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |