Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404102 | 0.91 | NR4A1 (0.59) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| SCHEMBL28342585 | 0.90 | NR4A1 (0.57) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| SCHEMBL27615559 | 0.90 | NR4A1 (0.57) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| Naphthoic Acid SCHEMBL7570532 | 0.79 | NR4A1 (0.81) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| SCHEMBL29290132 | 0.79 | KMT2A (0.60) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| Benzene SCHEMBL28284945 | 0.78 | NR4A1 (0.67) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| SCHEMBL27797485 | 0.77 | NR4A1 (0.59) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| Hydrazine SCHEMBL28964205 | 0.77 | NR4A1 (0.59) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| SCHEMBL27810842 | 0.76 | KMT2A (0.54) | NR4A1NR4A2NR4A3HPGDKDM4E | |
| SCHEMBL5987790 | 0.76 | NR4A1 (0.63) | NR4A1NR4A2NR4A3HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745022-B1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | ATON PHARMA INC (US) | 2014-08-13 | — | — | EP | claimed |
| US-8227636-B2 | Histone deacetylase inhibitor prodrugs | MERCK HDAC RESEARCH, LLC (US) | 2012-07-24 | — | — | US | claimed |
| EP-1745022-B1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | ATON PHARMA INC (US) | 2014-08-13 | — | — | EP | disclosed |
| US-8227636-B2 | Histone deacetylase inhibitor prodrugs | MERCK HDAC RESEARCH, LLC (US) | 2012-07-24 | — | — | US | disclosed |
| US-20090023786-A1 | Histone Deacetylase Inhibitor Prodrugs | ALTON PHARMA, INC. (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1745022-A1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | Aton Pharma, Inc. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005097747-A1 | HISTONE DEACETYLASE INHIBITOR PRODRUGS | ATON PHARMA, INC. (US) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023786-A1 | Histone Deacetylase Inhibitor Prodrugs | HDAC1, HDAC5, HDAC7 | NR4A1 2816/4885NR4A2 1997/4885NR4A3 1835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.