Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Brequinar. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH known ✓ | Q02127 | 19/20 | 0.98 |
| ▸ | DHFR | P00374 | 1/20 | 0.98 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.98 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brequinar SCHEMBL49400 | 0.99 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23832490 | 0.99 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL29688590 | 0.99 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL29355220 | 0.99 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL11906320 | 0.98 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23828306 | 0.98 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL21378179 | 0.98 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23113785 | 0.98 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL27742234 | 0.96 | DHODH (0.94) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL4177875 | 0.95 | DHODH (0.92) | DHODHDHFRALKBH5PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13188 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-12522572-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-01-13 | — | — | US | claimed |
| US-20250248989-A1 | STABLE POLYMORPHIC COMPOSITIONS OF BREQUINAR SODIUM AND METHODS OF USE AND MANUFACTURE THEREOF | CLEAR CREEK BIO INC (US) | 2025-08-07 | — | — | US | claimed |
| EP-4524131-A1 | SMALL MOLECULES FOR TREATING CANCER, INHABITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH | AlonBio Ltd. (IL) | 2025-03-19 | — | — | EP | claimed |
| US-12202803-B2 | Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death | ALONBIO LTD. (IL) | 2025-01-21 | — | — | US | claimed |
| US-20240343697-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2024-10-17 | — | — | US | claimed |
| US-12109219-B2 | Cannabinoid receptor modulators | ARENA PHARMACEUTICALS, INC. (US) | 2024-10-08 | — | — | US | claimed |
| US-12076315-B2 | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof | Clear Creek Bio, Inc. (US) | 2024-09-03 | — | — | US | claimed |
| WO-2024162488-A1 | PHARMACEUTICAL COMPOSITION COMPRISING CUCURBITACIN D FOR PREVENTING OR TREATING NEUROPATHIC PAIN | 주식회사 재인알앤피 | 2024-08-08 | — | — | WO | claimed |
| EP-4401780-A1 | AMORPHOUS PHOTOSENSITIZING PARTICLES, METHODS FOR THE PREPARATION THEREOF, AND METHODS FOR THE USE THEREOF | University of Maryland, College Park (US) | 2024-07-24 | — | — | EP | claimed |
| WO-1997016182-A1 | TRITERPENE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO., INC. (US) | 1997-05-09 | — | — | WO | claimed |
| WO-1997016437-A1 | TRITERPENE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO., INC. (US) | 1997-05-09 | — | — | WO | claimed |
| WO-1996040688-A1 | TRITERPENES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040170-A2 | METAL-CONTAINING COMPOUNDS AND THEIR USE FOR INHIBITING THE IMMUNE RESPONSE | PROCEPT, INC. (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996038178-A1 | ALLOGENEIC AND XENOGENEIC TRANSPLANTATION | THE GENERAL HOSPITAL CORPORATION (US) | 1996-12-05 | — | — | WO | claimed |
| WO-1996025936-A1 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | claimed |
| WO-1996013510-A1 | RUTHENIUM COMPLEXES AND THEIR USE AS IMMUNOSUPPRESSIVE AGENTS | PROCEPT, INC. (US) | 1996-05-09 | — | — | WO | claimed |
| US-5506228-A | 2,6-diaryl pyridazinones with immunosuppressant activity | MERCK & CO., INC. (US) | 1996-04-09 | — | — | US | claimed |
| EP-0393575-B1 | Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent | SEARLE & CO (US) | 1994-03-16 | — | — | EP | claimed |
| EP-0393575-A1 | Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent | G.D. Searle & Co. (US) | 1990-10-24 | — | — | EP | claimed |